T Cell Maturation Stage Prior to and During GMP Processing Informs on CAR T Cell Expansion in Patients

Autologous T cells were genetically modified to express a chimeric antigen receptor (CAR) directed toward carboxy-anhydrase-IX (CAIX) and used to treat patients with CAIX-positive metastatic renal cell carcinoma. In this study, we questioned whether the T cell maturation stage in the pre-infusion pr...

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Detalles Bibliográficos
Autores principales: Klaver, Yarne, van Steenbergen, Sabine C. L., Sleijfer, Stefan, Debets, Reno, Lamers, Cor H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183620/
https://www.ncbi.nlm.nih.gov/pubmed/28082983
http://dx.doi.org/10.3389/fimmu.2016.00648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183620/
https://www.ncbi.nlm.nih.gov/pubmed/28082983
http://dx.doi.org/10.3389/fimmu.2016.00648

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