Switching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker Studies

TGF-β induces complicated and even opposite responses in numerous biological processes, e.g., tumor suppression in pre-malignant cells and metastasis promotion in cancer cells. However, the cellular contextual determinants of these different TGF-β roles remain elusive, and the driver genes triggerin...

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Detalles Bibliográficos
Autores principales: Sun, Nan, Taguchi, Ayumu, Hanash, Samir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5184782/
https://www.ncbi.nlm.nih.gov/pubmed/27916872
http://dx.doi.org/10.3390/jcm5120109
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author Sun, Nan
Taguchi, Ayumu
Hanash, Samir
author_facet Sun, Nan
Taguchi, Ayumu
Hanash, Samir
author_sort Sun, Nan
collection PubMed
description TGF-β induces complicated and even opposite responses in numerous biological processes, e.g., tumor suppression in pre-malignant cells and metastasis promotion in cancer cells. However, the cellular contextual determinants of these different TGF-β roles remain elusive, and the driver genes triggering the determinants’ changes have not been identified. Recently, however, several findings have provided new insights on the contextual determinants of Smads in TGF-β’s biological processes. These novel switches and their effectors may serve as prognostic biomarkers and therapeutic targets of TGF-β-mediated cancer progression.
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spelling pubmed-51847822016-12-30 Switching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker Studies Sun, Nan Taguchi, Ayumu Hanash, Samir J Clin Med Review TGF-β induces complicated and even opposite responses in numerous biological processes, e.g., tumor suppression in pre-malignant cells and metastasis promotion in cancer cells. However, the cellular contextual determinants of these different TGF-β roles remain elusive, and the driver genes triggering the determinants’ changes have not been identified. Recently, however, several findings have provided new insights on the contextual determinants of Smads in TGF-β’s biological processes. These novel switches and their effectors may serve as prognostic biomarkers and therapeutic targets of TGF-β-mediated cancer progression. MDPI 2016-11-30 /pmc/articles/PMC5184782/ /pubmed/27916872 http://dx.doi.org/10.3390/jcm5120109 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sun, Nan
Taguchi, Ayumu
Hanash, Samir
Switching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker Studies
title Switching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker Studies
title_full Switching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker Studies
title_fullStr Switching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker Studies
title_full_unstemmed Switching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker Studies
title_short Switching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker Studies
title_sort switching roles of tgf-β in cancer development: implications for therapeutic target and biomarker studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5184782/
https://www.ncbi.nlm.nih.gov/pubmed/27916872
http://dx.doi.org/10.3390/jcm5120109
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