Optimized Cocktail Phenotyping Study Protocol Using Physiological Based Pharmacokinetic Modeling and In silico Assessment of Metabolic Drug–Drug Interactions Involving Modafinil

In vivo cocktail pathway phenotyping (ICPP) is routinely used to assess the metabolic drug–drug interaction (mDDI) potential of new drug candidates (NDC) during drug development. However, there are a number of potential limitations to this approach and the use of validated drug cocktails and study p...

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Detalles Bibliográficos
Autores principales: Rowland, Angela, Mangoni, Arduino A., Hopkins, Ashley, Sorich, Michael J., Rowland, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5186771/
https://www.ncbi.nlm.nih.gov/pubmed/28082902
http://dx.doi.org/10.3389/fphar.2016.00517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5186771/
https://www.ncbi.nlm.nih.gov/pubmed/28082902
http://dx.doi.org/10.3389/fphar.2016.00517

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