A neuronal network of mitochondrial dynamics regulates metastasis

The role of mitochondria in cancer is controversial. Using a genome-wide shRNA screen, we now show that tumours reprogram a network of mitochondrial dynamics operative in neurons, including syntaphilin (SNPH), kinesin KIF5B and GTPase Miro1/2 to localize mitochondria to the cortical cytoskeleton and...

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Detalles Bibliográficos
Autores principales: Caino, M. Cecilia, Seo, Jae Ho, Aguinaldo, Angeline, Wait, Eric, Bryant, Kelly G., Kossenkov, Andrew V., Hayden, James E., Vaira, Valentina, Morotti, Annamaria, Ferrero, Stefano, Bosari, Silvano, Gabrilovich, Dmitry I., Languino, Lucia R., Cohen, Andrew R., Altieri, Dario C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187409/
https://www.ncbi.nlm.nih.gov/pubmed/27991488
http://dx.doi.org/10.1038/ncomms13730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187409/
https://www.ncbi.nlm.nih.gov/pubmed/27991488
http://dx.doi.org/10.1038/ncomms13730

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