Cargando…

A neuronal network of mitochondrial dynamics regulates metastasis

The role of mitochondria in cancer is controversial. Using a genome-wide shRNA screen, we now show that tumours reprogram a network of mitochondrial dynamics operative in neurons, including syntaphilin (SNPH), kinesin KIF5B and GTPase Miro1/2 to localize mitochondria to the cortical cytoskeleton and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Caino, M. Cecilia, Seo, Jae Ho, Aguinaldo, Angeline, Wait, Eric, Bryant, Kelly G., Kossenkov, Andrew V., Hayden, James E., Vaira, Valentina, Morotti, Annamaria, Ferrero, Stefano, Bosari, Silvano, Gabrilovich, Dmitry I., Languino, Lucia R., Cohen, Andrew R., Altieri, Dario C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187409/ https://www.ncbi.nlm.nih.gov/pubmed/27991488 http://dx.doi.org/10.1038/ncomms13730

Ejemplares similares

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis
por: Seo, Jae Ho, et al.
Publicado: (2016)

Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability
por: Ghosh, Jagadish C., et al.
Publicado: (2022)

Deregulation of MiR-34b/Sox2 Predicts Prostate Cancer Progression
por: Forno, Irene, et al.
Publicado: (2015)

A cancer ubiquitome landscape identifies metabolic reprogramming as target of Parkin tumor suppression
por: Agarwal, Ekta, et al.
Publicado: (2021)

miR-296 regulation of a cell polarity-cell plasticity module controls tumor progression
por: Vaira, Valentina, et al.
Publicado: (2011)

Carcinosarcoma of the colon: report of a case with morphological, ultrastructural and molecular analysis
por: Ambrosini-Spaltro, Andrea, et al.
Publicado: (2006)

Survivin family proteins as novel molecular determinants of doxorubicin resistance in organotypic human breast tumors
por: Faversani, Alice, et al.
Publicado: (2014)

Mitochondrial fitness and cancer risk
por: Kossenkov, Andrew V., et al.
Publicado: (2022)

A New Mouse Avatar Model of Non-Small Cell Lung Cancer
por: Russo, Maria Veronica, et al.
Publicado: (2015)

Multicellular spheroids from normal and neoplastic thyroid tissues as a suitable model to test the effects of multikinase inhibitors
por: Cirello, Valentina, et al.
Publicado: (2016)

The Oncofetal Protein IMP3: A Novel Grading Tool and Predictor of Poor Clinical Outcome in Human Gliomas
por: Del Gobbo, Alessandro, et al.
Publicado: (2015)

miR-494-3p is a novel tumor driver of lung carcinogenesis
por: Faversani, Alice, et al.
Publicado: (2016)

Unique pattern of neutrophil migration and function during tumor progression
por: Patel, Sima, et al.
Publicado: (2018)

β1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation
por: Sayeed, Aejaz, et al.
Publicado: (2016)

Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression
por: Yeon, Minjeong, et al.
Publicado: (2023)

The Core Stem Genes SOX2, POU5F1/OCT4, and NANOG Are Expressed in Human Parathyroid Tumors and Modulated by MEN1, YAP1, and β-catenin Pathways Activation
por: Verdelli, Chiara, et al.
Publicado: (2021)

Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells
por: Krishn, Shiv Ram, et al.
Publicado: (2022)

Epigenetic Rewiring of Metastatic Cancer to the Brain: Focus on Lung and Colon Cancers
por: Morotti, Annamaria, et al.
Publicado: (2023)

Deletion of Cyclophilin D Impairs β-Oxidation and Promotes Glucose Metabolism
por: Tavecchio, Michele, et al.
Publicado: (2015)

The Contrasting Role of p16(Ink4A) Patterns of Expression in Neuroendocrine and Non-Neuroendocrine Lung Tumors: A Comprehensive Analysis with Clinicopathologic and Molecular Correlations
por: Fusco, Nicola, et al.
Publicado: (2015)

The Long Non-Coding BC200 Is a Novel Circulating Biomarker of Parathyroid Carcinoma
por: Morotti, Annamaria, et al.
Publicado: (2022)

Mitochondrial fission factor is a novel Myc-dependent regulator of mitochondrial permeability in cancer()
por: Seo, Jae Ho, et al.
Publicado: (2019)

Mismatch Repair Protein Loss as a Prognostic and Predictive Biomarker in Breast Cancers Regardless of Microsatellite Instability
por: Fusco, Nicola, et al.
Publicado: (2018)

Hepatic pseudocystic metastasis of well-differentiated ileal neuroendocrine tumor: a case report with review of the literature
por: Fiori, Stefano, et al.
Publicado: (2013)

Mitochondrial Fission and Fusion in Tumor Progression to Metastasis
por: Boulton, Dillon P., et al.
Publicado: (2022)

Histological evaluation of duodenal biopsies from coeliac patients: the need for different grading criteria during follow-up
por: Elli, Luca, et al.
Publicado: (2015)

AKT PHOSPHORYLATION OF MITOCHONDRIAL LonP1 PROTEASE ENABLES OXIDATIVE METABOLISM AND ADVANCED TUMOR TRAITS
por: Ghosh, Jagadish C., et al.
Publicado: (2019)

Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma
por: Augello, Claudia, et al.
Publicado: (2009)

HER2 aberrations and heterogeneity in cancers of the digestive system: Implications for pathologists and gastroenterologists
por: Fusco, Nicola, et al.
Publicado: (2016)

LANDSCAPE OF THE MITOCHONDRIAL Hsp90 METABOLOME IN TUMORS
por: Chae, Young Chan, et al.
Publicado: (2013)

Intercellular hif1α reprograms mammary progenitors and myeloid immune evasion to drive high-risk breast lesions
por: Bertolini, Irene, et al.
Publicado: (2023)

Specific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivo
por: Terrasi, Andrea, et al.
Publicado: (2019)

Pulmonary adenocarcinoma with massive lymphocytic infiltration: a case report with review of the literature of a rare histological entity with a peculiar biological behaviour
por: Del Gobbo, Alessandro, et al.
Publicado: (2013)

Fatal attraction: How macrophages participate in tumor metastases
por: Gabrilovich, Dmitry
Publicado: (2015)

Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment
por: Ma, Weili, et al.
Publicado: (2023)

A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy
por: Bryant, Kelly G., et al.
Publicado: (2017)

p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma
por: Giordano, Federica, et al.
Publicado: (2019)

Mitochondrial Dynamics in Type 2 Diabetes and Cancer
por: Williams, Michelle, et al.
Publicado: (2018)

Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs
por: Mastio, Jérôme, et al.
Publicado: (2019)

Mitochondria engage the integrated stress response to promote tumor growth
por: Boulton, Dillon P., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0pmdo8ctjofs9jpr2p05afg5cr