A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis

Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths, but its molecular heterogeneity hampers the design of targeted therapies. Currently, the only therapeutic option for advanced HCC is Sorafenib, an inhibitor whose targets include RAF. Unexpectedly, RAF1 expression is reduced in huma...

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Detalles Bibliográficos
Autores principales: Jeric, Ines, Maurer, Gabriele, Cavallo, Anna Lina, Raguz, Josipa, Desideri, Enrico, Tarkowski, Bartosz, Parrini, Matthias, Fischer, Irmgard, Zatloukal, Kurt, Baccarini, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187498/
https://www.ncbi.nlm.nih.gov/pubmed/28000790
http://dx.doi.org/10.1038/ncomms13781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187498/
https://www.ncbi.nlm.nih.gov/pubmed/28000790
http://dx.doi.org/10.1038/ncomms13781

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