Conformational Response of 30S-bound IF3 to A-Site Binders Streptomycin and Kanamycin

Aminoglycoside antibiotics are widely used to treat infectious diseases. Among them, streptomycin and kanamycin (and derivatives) are of importance to battle multidrug-resistant (MDR) Mycobacterium tuberculosis. Both drugs bind the small ribosomal subunit (30S) and inhibit protein synthesis. Genetic...

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Detalles Bibliográficos
Autores principales: Chulluncuy, Roberto, Espiche, Carlos, Nakamoto, Jose Alberto, Fabbretti, Attilio, Milón, Pohl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187519/
https://www.ncbi.nlm.nih.gov/pubmed/27983590
http://dx.doi.org/10.3390/antibiotics5040038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187519/
https://www.ncbi.nlm.nih.gov/pubmed/27983590
http://dx.doi.org/10.3390/antibiotics5040038

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