Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire

Plasma cells in human bone marrow (BM) are thought to be responsible for sustaining lifelong immunity, but its underlying basis is controversial. Here we use high-throughput sequence analysis of the same individual across 6.5 years to show that the BM plasma cell immunoglobulin heavy chain repertoir...

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Detalles Bibliográficos
Autores principales: Wu, Gabriel C., Cheung, Nai-Kong V., Georgiou, George, Marcotte, Edward M., Ippolito, Gregory C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187582/
https://www.ncbi.nlm.nih.gov/pubmed/28000661
http://dx.doi.org/10.1038/ncomms13838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187582/
https://www.ncbi.nlm.nih.gov/pubmed/28000661
http://dx.doi.org/10.1038/ncomms13838

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