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Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands

Cytoplasmic dynein mediates retrograde transport in axons, but it is unknown how its transport characteristics are regulated to meet acutely changing demands. We find that stimulus-induced retrograde transport of different cargos requires the local synthesis of different dynein cofactors. Nerve grow...

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Detalles Bibliográficos
Autores principales: Villarin, Joseph M., McCurdy, Ethan P., Martínez, José C., Hengst, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187584/
https://www.ncbi.nlm.nih.gov/pubmed/28000671
http://dx.doi.org/10.1038/ncomms13865