A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation

Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization and there remains no pediatric vaccine. RSV live-attenuated vaccines (LAVs) have a history of safe testing in infants; however, achieving an effective balance of attenuation and immunogenicity has proven challenging. Here...

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Detalles Bibliográficos
Autores principales: Stobart, Christopher C., Rostad, Christina A., Ke, Zunlong, Dillard, Rebecca S., Hampton, Cheri M., Strauss, Joshua D., Yi, Hong, Hotard, Anne L., Meng, Jia, Pickles, Raymond J., Sakamoto, Kaori, Lee, Sujin, Currier, Michael G., Moin, Syed M., Graham, Barney S., Boukhvalova, Marina S., Gilbert, Brian E., Blanco, Jorge C. G., Piedra, Pedro A., Wright, Elizabeth R., Moore, Martin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187593/
https://www.ncbi.nlm.nih.gov/pubmed/28000669
http://dx.doi.org/10.1038/ncomms13916

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187593/
https://www.ncbi.nlm.nih.gov/pubmed/28000669
http://dx.doi.org/10.1038/ncomms13916

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