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The Double Role of p53 in Cancer and Autoimmunity and Its Potential as Therapeutic Target
p53 is a sequence-specific short-lived transcription factor expressed at low concentrations in various tissues while it is upregulated in damaged, tumoral or inflamed tissue. In normally proliferating cells, p53 protein levels and function are tightly controlled by main regulators, i.e., MDM2 (mouse...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187775/ https://www.ncbi.nlm.nih.gov/pubmed/27897991 http://dx.doi.org/10.3390/ijms17121975 |