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Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex
TP53 is one of the most frequently-mutated and deleted tumor suppressors in cancer, with a dramatic correlation with dismal prognoses. In addition to genetic inactivation, the p53 protein can be functionally inactivated in cancer, through post-transductional modifications, changes in cellular compar...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187797/ https://www.ncbi.nlm.nih.gov/pubmed/27916821 http://dx.doi.org/10.3390/ijms17121997 |