Abnormal Mitochondrial cAMP/PKA Signaling Is Involved in Sepsis-Induced Mitochondrial and Myocardial Dysfunction

Adrenergic receptors couple to Gs-proteins leading to transmembrane adenylyl cyclase activation and cytosolic cyclic adenosine monophosphate (cAMP) production. Cyclic AMP is also produced in the mitochondrial matrix, where it regulates respiration through protein kinase A (PKA)-dependent phosphoryla...

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Detalles Bibliográficos
Autores principales: Neviere, Remi, Delguste, Florian, Durand, Arthur, Inamo, Jocelyn, Boulanger, Eric, Preau, Sebastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187875/
https://www.ncbi.nlm.nih.gov/pubmed/27973394
http://dx.doi.org/10.3390/ijms17122075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187875/
https://www.ncbi.nlm.nih.gov/pubmed/27973394
http://dx.doi.org/10.3390/ijms17122075

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