Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in Pten(LoxP/LoxP);Braf(CA/+) Mice

Current genetically-engineered mouse melanoma models are often based on Tyr::CreER(T2)-controlled MAPK pathway activation by the BRAF(V600E) mutation and PI3K pathway activation by loss of PTEN. The major drawback of these models is the occurrence of spontaneous tumors caused by leakiness of the Tyr...

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Detalles Bibliográficos
Autores principales: Deken, Marcel A., Song, Ji-Ying, Gadiot, Jules, Bins, Adriaan D., Kroon, Paula, Verbrugge, Inge, Blank, Christian U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187949/
https://www.ncbi.nlm.nih.gov/pubmed/27999416
http://dx.doi.org/10.3390/ijms17122149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187949/
https://www.ncbi.nlm.nih.gov/pubmed/27999416
http://dx.doi.org/10.3390/ijms17122149

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