Synthesis, Bioevaluation and Molecular Dynamic Simulation Studies of Dexibuprofen–Antioxidant Mutual Prodrugs

Dexibuprofen–antioxidant conjugates were synthesized with the aim to reduce its gastrointestinal effects. The esters analogs of dexibuprofen 5a–c were obtained by reacting its –COOH group with chloroacetyl derivatives 3a–c. The in vitro hydrolysis data confirmed that synthesized prodrugs 5a–c were s...

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Detalles Bibliográficos
Autores principales: Ashraf, Zaman, Alamgeer, Rasool, Raqiqatur, Hassan, Mubashir, Ahsan, Haseeb, Afzal, Samina, Afzal, Khurram, Cho, Hongsik, Kim, Song Ja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187951/
https://www.ncbi.nlm.nih.gov/pubmed/28009827
http://dx.doi.org/10.3390/ijms17122151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187951/
https://www.ncbi.nlm.nih.gov/pubmed/28009827
http://dx.doi.org/10.3390/ijms17122151

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