Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor Evolution

Identification of cancer driver genes using somatic mutation patterns indicative of positive selection has become a major goal in cancer genomics. However, cancer cells additionally depend on a large number of genes involved in basic cellular processes. While such genes should in theory be subject t...

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Detalles Bibliográficos
Autores principales: Van den Eynden, Jimmy, Basu, Swaraj, Larsson, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189942/
https://www.ncbi.nlm.nih.gov/pubmed/28027311
http://dx.doi.org/10.1371/journal.pgen.1006506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189942/
https://www.ncbi.nlm.nih.gov/pubmed/28027311
http://dx.doi.org/10.1371/journal.pgen.1006506

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