New open conformation of SMYD3 implicates conformational selection and allostery

SMYD3 plays a key role in cancer cell viability, adhesion, migration and invasion. SMYD3 promotes formation of inducible regulatory T cells and is involved in reducing autoimmunity. However, the nearly “closed” substrate-binding site and poor in vitro H3K4 methyltransferase activity have obscured fu...

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Detalles Bibliográficos
Autores principales: Spellmon, Nicholas, Sun, Xiaonan, Xue, Wen, Holcomb, Joshua, Chakravarthy, Srinivas, Shang, Weifeng, Edwards, Brian, Sirinupong, Nualpun, Li, Chunying, Yang, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189988/
https://www.ncbi.nlm.nih.gov/pubmed/28050603
http://dx.doi.org/10.3934/biophy.2017.1.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189988/
https://www.ncbi.nlm.nih.gov/pubmed/28050603
http://dx.doi.org/10.3934/biophy.2017.1.1

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