Human HLA-A*02:01/CHM1(+) allo-restricted T cell receptor transgenic CD8(+) T Cells specifically inhibit Ewing sarcoma growth in vitro and in vivo

The endochondral bone protein Chondromodulin-I (CHM1) provides oncogene addiction in Ewing sarcoma (ES). We pre-clinically tested the targetability of CHM1 by TCR transgenic, allo-restricted, peptide specific T cells to treat ES. We previously generated allo-restricted wildtype CD8(+) T cells direct...

Descripción completa

Detalles Bibliográficos
Autores principales: Blaeschke, Franziska, Thiel, Uwe, Kirschner, Andreas, Thiede, Melanie, Rubio, Rebeca Alba, Schirmer, David, Kirchner, Thomas, Richter, Gunther H.S., Mall, Sabine, Klar, Richard, Riddell, Stanley, Busch, Dirk H., Krackhardt, Angela, Grunewald, Thomas G.P., Burdach, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190022/
https://www.ncbi.nlm.nih.gov/pubmed/27281613
http://dx.doi.org/10.18632/oncotarget.9218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190022/
https://www.ncbi.nlm.nih.gov/pubmed/27281613
http://dx.doi.org/10.18632/oncotarget.9218

Ejemplares similares