The impact of intermittent versus continuous exposure to EGFR tyrosine kinase inhibitor on selection of EGFR T790M-mutant drug-resistant clones in a lung cancer cell line carrying activating EGFR mutation

Drug-resistant cell lines are essential tools for investigating the mechanisms of resistance to molecular-targeted anti-cancer drugs. However, little is known about how to establish clinically relevant drug-resistant cell lines. Our study examined the impact of a drug-free period on the establishmen...

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Detalles Bibliográficos
Autores principales: Lee, Youngjoo, Choi, Yu-Ra, Kim, Kyoung-Yeon, Shin, Dong Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190025/
https://www.ncbi.nlm.nih.gov/pubmed/27270313
http://dx.doi.org/10.18632/oncotarget.9703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190025/
https://www.ncbi.nlm.nih.gov/pubmed/27270313
http://dx.doi.org/10.18632/oncotarget.9703

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