ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosis

Glioblastoma multiforme (GBM) is a deadly grade IV brain tumor. Radiation in combination with temozolomide (TMZ), the current chemotherapeutic for GBMs, only provides 12–14 months survival post diagnosis. Because GBMs are dependent on both activation of the DNA damage pathway and the endoplasmic ret...

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Detalles Bibliográficos
Autores principales: Weatherbee, Jessica L., Kraus, Jean-Louis, Ross, Alonzo H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190062/
https://www.ncbi.nlm.nih.gov/pubmed/27286262
http://dx.doi.org/10.18632/oncotarget.9907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190062/
https://www.ncbi.nlm.nih.gov/pubmed/27286262
http://dx.doi.org/10.18632/oncotarget.9907

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