Cargando…

Inhibition of histone deacetylases induces formation of multipolar spindles and subsequent p53-dependent apoptosis in nasopharyngeal carcinoma cells

Histone deacetylases (HDACs) play crucial roles in the initiation and progression of cancer, offering a promising target for cancer therapy. HDACs inhibitor MGCD0103 (MGCD) exhibits effective anti-tumor activity by blocking proliferation and inducing cell death in malignant cells. However, the molec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Min, Qian, Yuan-min, Yue, Cai-feng, Wang, Zi-feng, Wang, Bi-cheng, Zhang, Wei, Zheng, Fei-meng, Liu, Quentin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190087/ https://www.ncbi.nlm.nih.gov/pubmed/27283770 http://dx.doi.org/10.18632/oncotarget.9922

Ejemplares similares

Induction of Spindle Multipolarity by Centrosomal Cluster Inhibition
por: Krämer, Alwin, et al.
Publicado: (2008)

Disturbed chromosome segregation and multipolar spindle formation in a patient with CHAMP1 mutation
por: Okamoto, Nobuhiko, et al.
Publicado: (2017)

Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8
por: Yan, Wensheng, et al.
Publicado: (2012)

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma
por: Phimmachanh, Monica, et al.
Publicado: (2020)

Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53 Signaling Pathway Activation
por: Deng, Zhantao, et al.
Publicado: (2016)

Diverse microtubule-targeted anticancer agents kill cells by inducing chromosome missegregation on multipolar spindles
por: Zhou, Amber S., et al.
Publicado: (2023)

Combination of Proteasome and Histone Deacetylase Inhibitors Overcomes the Impact of Gain-of-Function p53 Mutations
por: Meng, Xiangbing, et al.
Publicado: (2018)

p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors
por: Sonnemann, J, et al.
Publicado: (2014)

Dissection of Anti-tumor Activity of Histone Deacetylase Inhibitor SAHA in Nasopharyngeal Carcinoma Cells via Quantitative Phosphoproteomics
por: Huang, Huichao, et al.
Publicado: (2020)

Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils
por: Kankaanranta, Hannu, et al.
Publicado: (2010)

Beyond Histone and Deacetylase: An Overview of Cytoplasmic Histone Deacetylases and Their Nonhistone Substrates
por: Yao, Ya-Li, et al.
Publicado: (2011)

p53 Dependent Centrosome Clustering Prevents Multipolar Mitosis in Tetraploid Cells
por: Yi, Qiyi, et al.
Publicado: (2011)

Histone Deacetylase Inhibitor-Induced Autophagy in Tumor Cells: Implications for p53
por: Mrakovcic, Maria, et al.
Publicado: (2017)

Compromised MPS1 Activity Induces Multipolar Spindle Formation in Oocytes From Aged Mares: Establishing the Horse as a Natural Animal Model to Study Age-Induced Oocyte Meiotic Spindle Instability
por: Rizzo, Marilena, et al.
Publicado: (2021)

Histone deacetylase inhibitors facilitate partner preference formation in female prairie voles
por: Wang, Hui, et al.
Publicado: (2013)

Histone deacetylase inhibitor induces cell apoptosis and cycle arrest in lung cancer cells via mitochondrial injury and p53 up-acetylation
por: Bao, Lianmin, et al.
Publicado: (2016)

Histone Deacetylases and Histone Deacetylase Inhibitors: Molecular Mechanisms of Action in Various Cancers
por: Sanaei, Masumeh, et al.
Publicado: (2019)

Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy
por: Stankov, Metodi V., et al.
Publicado: (2013)

NOXA Accentuates Apoptosis Induction by a Novel Histone Deacetylase Inhibitor
por: Ashry, Ramy, et al.
Publicado: (2023)

Antihydrogen formation dynamics in a multipolar neutral anti-atom trap
por: Andresen, G.B., et al.
Publicado: (2010)

Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response
por: Kao, Gary D., et al.
Publicado: (2003)

Histone deacetylase 3, not histone deacetylase 2, interacts with the major immediate early locus of human cytomegalovirus
por: Huang, Ying, et al.
Publicado: (2011)

Apoptosis Induction byHistone Deacetylase Inhibitors in Cancer Cells: Role of Ku70
por: Gong, Ping, et al.
Publicado: (2019)

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells
por: Silkworth, William T., et al.
Publicado: (2009)

Histone deacetylase inhibitors prevent H(2)O(2) from inducing stress granule formation
por: Feng, Siyuan, et al.
Publicado: (2020)

Histone deacetylase inhibitor sodium butyrate suppresses proliferation and promotes apoptosis in osteosarcoma cells by regulation of the MDM2–p53 signaling
por: Xie, Chuhai, et al.
Publicado: (2016)

Molecular mechanisms of histone deacetylases and inhibitors in renal fibrosis progression
por: Wang, Jiayu, et al.
Publicado: (2022)

DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression
por: Chen, Wei-Ju, et al.
Publicado: (2017)

Multipolar representation of protein structure
por: Gramada, Apostol, et al.
Publicado: (2006)

Measurements of multipolarities in $^{225}$Ra
por: Andersen, E, et al.
Publicado: (1988)

Multipolar electrode spline embolization
por: Hussain, Mohammad A., et al.
Publicado: (2017)

The application of histone deacetylases inhibitors in glioblastoma
por: Chen, Rui, et al.
Publicado: (2020)

Chemical Phylogenetics of Histone Deacetylases
por: Bradner, James E., et al.
Publicado: (2010)

Histone deacetylases in viral infections
por: Herbein, Georges, et al.
Publicado: (2010)

Butyrate Histone Deacetylase Inhibitors
por: Steliou, Kosta, et al.
Publicado: (2012)

Histone deacetylase signaling in cardioprotection
por: Lehmann, Lorenz H., et al.
Publicado: (2013)

Histone deacetylase 6 in cancer
por: Li, Ting, et al.
Publicado: (2018)

Targeting histone deacetylases: perspectives for epigenetic-based therapy in cardio-cerebrovascular disease
por: Wang, Zi-Ying, et al.
Publicado: (2015)

A Single-Celled Metasurface for Multipolarization Generation and Wavefront Manipulation
por: Ji, Ruonan, et al.
Publicado: (2022)

Histone Deacetylase Inhibitors Sensitize TRAIL-Induced Apoptosis in Colon Cancer Cells
por: Zhang, Baojie, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_dq8vcm98u4t03g05ss9lejenf4