Down regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR/ABL in hematopoietic cells

DNA-damaging chemotherapeutic agents activate apoptotic pathways in cancer cells. However, they also activate checkpoint mechanisms mainly involving Chk1 and p53 to arrest cell cycle progression, thus abbreviating their cytotoxic effects. We previously found that aberrant tyrosine kinases involved i...

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Detalles Bibliográficos
Autores principales: Umezawa, Yoshihiro, Kurosu, Tetsuya, Akiyama, Hiroki, Wu, Nang, Nogami, Ayako, Nagao, Toshikage, Miura, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190110/
https://www.ncbi.nlm.nih.gov/pubmed/27286446
http://dx.doi.org/10.18632/oncotarget.9844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190110/
https://www.ncbi.nlm.nih.gov/pubmed/27286446
http://dx.doi.org/10.18632/oncotarget.9844

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