Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function

Skeletal muscle is a highly regenerative tissue, but muscle repair potential is increasingly compromised with advancing age. In this study, we demonstrate that increased NF-κB activity in aged muscle fibers contributes to diminished myogenic potential of their associated satellite cells. We further...

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Detalles Bibliográficos
Autores principales: Oh, Juhyun, Sinha, Indranil, Tan, Kah Yong, Rosner, Bernard, Dreyfuss, Jonathan M., Gjata, Ornela, Tran, Peter, Shoelson, Steven E., Wagers, Amy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191876/
https://www.ncbi.nlm.nih.gov/pubmed/27852976
http://dx.doi.org/10.18632/aging.101098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191876/
https://www.ncbi.nlm.nih.gov/pubmed/27852976
http://dx.doi.org/10.18632/aging.101098

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