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Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function
Skeletal muscle is a highly regenerative tissue, but muscle repair potential is increasingly compromised with advancing age. In this study, we demonstrate that increased NF-κB activity in aged muscle fibers contributes to diminished myogenic potential of their associated satellite cells. We further...
Autores principales: | Oh, Juhyun, Sinha, Indranil, Tan, Kah Yong, Rosner, Bernard, Dreyfuss, Jonathan M., Gjata, Ornela, Tran, Peter, Shoelson, Steven E., Wagers, Amy J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191876/ https://www.ncbi.nlm.nih.gov/pubmed/27852976 http://dx.doi.org/10.18632/aging.101098 |
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