Active-Site Protonation States in an Acyl-Enzyme Intermediate of a Class A β-Lactamase with a Monobactam Substrate

The monobactam antibiotic aztreonam is used to treat cystic fibrosis patients with chronic pulmonary infections colonized by Pseudomonas aeruginosa strains expressing CTX-M extended-spectrum β-lactamases. The protonation states of active-site residues that are responsible for hydrolysis have been de...

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Detalles Bibliográficos
Autores principales: Vandavasi, Venu Gopal, Langan, Patricia S., Weiss, Kevin L., Parks, Jerry M., Cooper, Jonathan B., Ginell, Stephan L., Coates, Leighton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192116/
https://www.ncbi.nlm.nih.gov/pubmed/27795378
http://dx.doi.org/10.1128/AAC.01636-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192116/
https://www.ncbi.nlm.nih.gov/pubmed/27795378
http://dx.doi.org/10.1128/AAC.01636-16

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