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Critical Evaluation of Molecular Monitoring in Malaria Drug Efficacy Trials and Pitfalls of Length-Polymorphic Markers

Estimation of drug efficacy in antimalarial drug trials requires parasite genotyping to distinguish new infections from treatment failures. When using length-polymorphic molecular markers, preferential amplification of short fragments can compromise detection of coinfections, potentially leading to...

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Detalles Bibliográficos
Autores principales:	Messerli, Camilla, Hofmann, Natalie E., Beck, Hans-Peter, Felger, Ingrid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Epidemiology and Surveillance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192142/ https://www.ncbi.nlm.nih.gov/pubmed/27821442 http://dx.doi.org/10.1128/AAC.01500-16

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