Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt

Hepatic stellate cell (HSC) activation on liver injury facilitates fibrosis. Hepatokines affecting HSCs are largely unknown. Here we show that hepcidin inhibits HSC activation and ameliorates liver fibrosis. We observe that hepcidin levels are inversely correlated with exacerbation of fibrosis in pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Chang Yeob, Koo, Ja Hyun, Kim, Sung Hoon, Gardenghi, Sara, Rivella, Stefano, Strnad, Pavel, Hwang, Se Jin, Kim, Sang Geon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192182/
https://www.ncbi.nlm.nih.gov/pubmed/28004654
http://dx.doi.org/10.1038/ncomms13817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192182/
https://www.ncbi.nlm.nih.gov/pubmed/28004654
http://dx.doi.org/10.1038/ncomms13817

Ejemplares similares