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Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy
The development of a tuberculosis (TB) vaccine that induces sterilizing immunity to Mycobacterium tuberculosis infection has been elusive. Absence of sterilizing immunity induced by TB vaccines may be due to delayed activation of mucosal dendritic cells (DCs), and subsequent delay in antigen present...
Autores principales: | Griffiths, Kristin L., Ahmed, Mushtaq, Das, Shibali, Gopal, Radha, Horne, William, Connell, Terry D., Moynihan, Kelly D., Kolls, Jay K., Irvine, Darrell J., Artyomov, Maxim N., Rangel-Moreno, Javier, Khader, Shabaana A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192216/ https://www.ncbi.nlm.nih.gov/pubmed/28004802 http://dx.doi.org/10.1038/ncomms13894 |
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