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Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity
When a T cell infiltrates a tumor, it is subjected to a variety of immunosuppressive and regulatory signals in the microenvironment. However, it is becoming increasingly clear that due to the proliferative and energetically-deregulated nature of tumor cells, T cells also operate at a metabolic disad...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192366/ https://www.ncbi.nlm.nih.gov/pubmed/27929420 http://dx.doi.org/10.3390/vaccines4040046 |
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author | Scharping, Nicole E. Delgoffe, Greg M. |
author_facet | Scharping, Nicole E. Delgoffe, Greg M. |
author_sort | Scharping, Nicole E. |
collection | PubMed |
description | When a T cell infiltrates a tumor, it is subjected to a variety of immunosuppressive and regulatory signals in the microenvironment. However, it is becoming increasingly clear that due to the proliferative and energetically-deregulated nature of tumor cells, T cells also operate at a metabolic disadvantage. The nutrient dearth of the tumor microenvironment (TME) creates “metabolic checkpoints” upon infiltrating T cells, impacting their ability to survive, proliferate and function effectively. In this review, we summarize the basics of tumor cell and T cell metabolism and discuss recent advances elucidating the individual metabolic checkpoints exerted on T cells that drive their dysfunction in the TME. |
format | Online Article Text |
id | pubmed-5192366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-51923662017-01-03 Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity Scharping, Nicole E. Delgoffe, Greg M. Vaccines (Basel) Review When a T cell infiltrates a tumor, it is subjected to a variety of immunosuppressive and regulatory signals in the microenvironment. However, it is becoming increasingly clear that due to the proliferative and energetically-deregulated nature of tumor cells, T cells also operate at a metabolic disadvantage. The nutrient dearth of the tumor microenvironment (TME) creates “metabolic checkpoints” upon infiltrating T cells, impacting their ability to survive, proliferate and function effectively. In this review, we summarize the basics of tumor cell and T cell metabolism and discuss recent advances elucidating the individual metabolic checkpoints exerted on T cells that drive their dysfunction in the TME. MDPI 2016-12-06 /pmc/articles/PMC5192366/ /pubmed/27929420 http://dx.doi.org/10.3390/vaccines4040046 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Scharping, Nicole E. Delgoffe, Greg M. Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity |
title | Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity |
title_full | Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity |
title_fullStr | Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity |
title_full_unstemmed | Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity |
title_short | Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity |
title_sort | tumor microenvironment metabolism: a new checkpoint for anti-tumor immunity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192366/ https://www.ncbi.nlm.nih.gov/pubmed/27929420 http://dx.doi.org/10.3390/vaccines4040046 |
work_keys_str_mv | AT scharpingnicolee tumormicroenvironmentmetabolismanewcheckpointforantitumorimmunity AT delgoffegregm tumormicroenvironmentmetabolismanewcheckpointforantitumorimmunity |