Cargando…

Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes

Parkinson’s disease and other alpha-synucleinopathies are progressive neurodegenerative diseases characterized by aggregates of misfolded alpha-synuclein spreading throughout the brain. Recent evidence suggests that the pathological progression is likely due to neuron-to-neuron transfer of these agg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Domert, Jakob, Sackmann, Christopher, Severinsson, Emelie, Agholme, Lotta, Bergström, Joakim, Ingelsson, Martin, Hallbeck, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193351/ https://www.ncbi.nlm.nih.gov/pubmed/28030591 http://dx.doi.org/10.1371/journal.pone.0168700

Ejemplares similares

Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia
por: Sackmann, Valerie, et al.
Publicado: (2019)

Binding of α-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes
por: Reyes, Juan F., et al.
Publicado: (2019)

Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes
por: Rostami, Jinar, et al.
Publicado: (2017)

Altered Distribution of SNARE Proteins in Primary Neurons Exposed to Different Alpha-Synuclein Proteoforms
por: Brolin, Emma, et al.
Publicado: (2023)

Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein
por: Almandoz-Gil, Leire, et al.
Publicado: (2016)

Studies on alpha-synuclein and islet amyloid polypeptide interaction
por: Wang, Ye, et al.
Publicado: (2023)

TDP-43 Is Efficiently Transferred Between Neuron-Like Cells in a Manner Enhanced by Preservation of Its N-Terminus but Independent of Extracellular Vesicles
por: Sackmann, Christopher, et al.
Publicado: (2020)

Modeling Parkinson's disease‐related symptoms in alpha‐synuclein overexpressing mice
por: Aniszewska, Agata, et al.
Publicado: (2022)

Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
por: Gustafsson, Gabriel, et al.
Publicado: (2017)

In Situ Proximity Ligation Assay Reveals Co-Localization of Alpha-Synuclein and SNARE Proteins in Murine Primary Neurons
por: Almandoz-Gil, Leire, et al.
Publicado: (2018)

Oligomeric amyloid-β induces early and widespread changes to the proteome in human iPSC-derived neurons
por: Sackmann, Christopher, et al.
Publicado: (2020)

Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models
por: Drobny, Alice, et al.
Publicado: (2023)

Antibodies against Alpha-Synuclein Reduce Oligomerization in Living Cells
por: Näsström, Thomas, et al.
Publicado: (2011)

Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells
por: Gustafsson, Gabriel, et al.
Publicado: (2018)

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
por: Qiao, Liyan, et al.
Publicado: (2008)

Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice
por: Roshanbin, Sahar, et al.
Publicado: (2021)

Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates
por: Rostami, Jinar, et al.
Publicado: (2021)

Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose
por: Hoffmann, Anna-Carin, et al.
Publicado: (2019)

Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson’s disease
por: Reyes, Juan F., et al.
Publicado: (2021)

Exposure of α-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease
por: Moudio, Serge, et al.
Publicado: (2022)

SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine
por: Zhu, Lin-nan, et al.
Publicado: (2018)

Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates
por: Elfarrash, Sara, et al.
Publicado: (2019)

Aggregation of alpha-synuclein in enteric neurons does not impact function in vitro
por: Bindas, Adam J., et al.
Publicado: (2022)

Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders
por: Ingelsson, Martin
Publicado: (2016)

Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression
por: Bartels, Martin, et al.
Publicado: (2019)

Alpha-Synuclein Aggregation in Parkinson's Disease
por: Srinivasan, E., et al.
Publicado: (2021)

Early fine motor impairment and behavioral dysfunction in (Thy‐1)‐h[A30P] alpha‐synuclein mice
por: Ekmark‐Lewén, Sara, et al.
Publicado: (2018)

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum
por: Miraglia, Fabiana, et al.
Publicado: (2020)

The Convergence of Alpha-Synuclein, Mitochondrial, and Lysosomal Pathways in Vulnerability of Midbrain Dopaminergic Neurons in Parkinson’s Disease
por: Minakaki, Georgia, et al.
Publicado: (2020)

Cerebrospinal Fluid Lysosomal Enzymes and Alpha-Synuclein in Parkinson's Disease
por: Parnetti, Lucilla, et al.
Publicado: (2014)

Modulation of Alpha-Synuclein Aggregation by Dopamine Analogs
por: Latawiec, Diane, et al.
Publicado: (2010)

Insights Into Peptide Inhibition of Alpha-Synuclein Aggregation
por: Torpey, James H., et al.
Publicado: (2020)

Loss of β-Glucocerebrosidase Activity Does Not Affect Alpha-Synuclein Levels or Lysosomal Function in Neuronal Cells
por: Dermentzaki, Georgia, et al.
Publicado: (2013)

Detection of pathological alpha-synuclein aggregates in human iPSC-derived neurons and tissue
por: Stojkovska, Iva, et al.
Publicado: (2021)

Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells
por: Vasili, Eftychia, et al.
Publicado: (2022)

Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo
por: Angot, Elodie, et al.
Publicado: (2012)

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
por: Alvarez-Erviti, Lydia, et al.
Publicado: (2011)

Saposin C, Key Regulator in the Alpha-Synuclein Degradation Mediated by Lysosome
por: Ruz, Clara, et al.
Publicado: (2022)

Conformational templating of α-synuclein aggregates in neuronal-glial cultures
por: Sacino, Amanda N, et al.
Publicado: (2013)

Correction: Loss of β-Glucocerebrosidase Activity Does Not Affect Alpha-Synuclein Levels or Lysosomal Function in Neuronal Cells
por: Dermentzaki, Georgia, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lpdaapf6fb7950m5nbak8r67b2