Therapeutic Targeting of the Mitochondria Initiates Excessive Superoxide Production and Mitochondrial Depolarization Causing Decreased mtDNA Integrity

Mitochondrial dysregulation is closely associated with excessive reactive oxygen species (ROS) production. Altered redox homeostasis has been implicated in the onset of several diseases including cancer. Mitochondrial DNA (mtDNA) and proteins are particularly sensitive to ROS as they are in close pr...

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Detalles Bibliográficos
Autores principales: Pokrzywinski, Kaytee L., Biel, Thomas G., Kryndushkin, Dmitry, Rao, V. Ashutosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193408/
https://www.ncbi.nlm.nih.gov/pubmed/28030582
http://dx.doi.org/10.1371/journal.pone.0168283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193408/
https://www.ncbi.nlm.nih.gov/pubmed/28030582
http://dx.doi.org/10.1371/journal.pone.0168283

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