Hepatocyte Hypoxia Inducible Factor-1 Mediates the Development of Liver Fibrosis in a Mouse Model of Nonalcoholic Fatty Liver Disease

BACKGROUND: Obstructive sleep apnea (OSA) is associated with the progression of non-alcoholic fatty liver disease (NAFLD) to steatohepatitis and fibrosis. This progression correlates with the severity of OSA-associated hypoxia. In mice with diet induced obesity, hepatic steatosis leads to liver tiss...

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Detalles Bibliográficos
Autores principales: Mesarwi, Omar A., Shin, Mi-Kyung, Bevans-Fonti, Shannon, Schlesinger, Christina, Shaw, Janet, Polotsky, Vsevolod Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193414/
https://www.ncbi.nlm.nih.gov/pubmed/28030556
http://dx.doi.org/10.1371/journal.pone.0168572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193414/
https://www.ncbi.nlm.nih.gov/pubmed/28030556
http://dx.doi.org/10.1371/journal.pone.0168572

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