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Two Bistable Switches Govern M Phase Entry

The abrupt and irreversible transition from interphase to M phase is essential to separate DNA replication from chromosome segregation. This transition requires the switch-like phosphorylation of hundreds of proteins by the cyclin-dependent kinase 1 (Cdk1):cyclin B (CycB) complex. Previous studies h...

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Detalles Bibliográficos
Autores principales: Mochida, Satoru, Rata, Scott, Hino, Hirotsugu, Nagai, Takeharu, Novák, Béla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196020/
https://www.ncbi.nlm.nih.gov/pubmed/27889260
http://dx.doi.org/10.1016/j.cub.2016.10.022