Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53

The tumour suppressor p53 transactivates the expression of its target genes to exert its functions. Here, we identify a pleckstrin homology domain-containing protein (PHLDB3)-encoding gene as a p53 target. PHLDB3 overexpression increases proliferation and restrains apoptosis of wild-type p53-harbori...

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Detalles Bibliográficos
Autores principales: Chao, Tengfei, Zhou, Xiang, Cao, Bo, Liao, Peng, Liu, Hongbing, Chen, Yun, Park, Hee-Won, Zeng, Shelya X., Lu, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196188/
https://www.ncbi.nlm.nih.gov/pubmed/28008906
http://dx.doi.org/10.1038/ncomms13755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196188/
https://www.ncbi.nlm.nih.gov/pubmed/28008906
http://dx.doi.org/10.1038/ncomms13755

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