(S)-5-ethynyl-anabasine, a novel compound, is a more potent agonist than other nicotine alkaloids on the nematode Asu-ACR-16 receptor

Nematode parasites infect ∼2 billion people world-wide. Infections are treated and prevented by anthelmintic drugs, some of which act on nicotinic acetylcholine receptors (nAChRs). There is an unmet need for novel therapeutic agents because of concerns about the development of resistance. We have se...

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Detalles Bibliográficos
Autores principales: Zheng, Fudan, Du, Xiangwei, Chou, Tsung-Han, Robertson, Alan P., Yu, Edward W., VanVeller, Brett, Martin, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196235/
https://www.ncbi.nlm.nih.gov/pubmed/28033523
http://dx.doi.org/10.1016/j.ijpddr.2016.12.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196235/
https://www.ncbi.nlm.nih.gov/pubmed/28033523
http://dx.doi.org/10.1016/j.ijpddr.2016.12.001

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