ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons

Nonsense-mediated mRNA decay (NMD) represents a eukaryotic quality control pathway that recognizes and rapidly degrades transcripts harbouring nonsense mutations to limit accumulation of non-functional and potentially toxic truncated polypeptides. A critical component of the NMD machinery is UPF1, a...

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Detalles Bibliográficos
Autores principales: Serdar, Lucas D., Whiteside, DaJuan L., Baker, Kristian E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196439/
https://www.ncbi.nlm.nih.gov/pubmed/28008922
http://dx.doi.org/10.1038/ncomms14021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196439/
https://www.ncbi.nlm.nih.gov/pubmed/28008922
http://dx.doi.org/10.1038/ncomms14021

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