Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist

5-hydroxytryptamine (5-HT) is a key regulator of muscle contraction in parasitic flatworms. In Schistosoma mansoni, the myoexcitatory action of 5-HT is effected through activation of a serotonergic GPCR (Sm.5HTR(L)), prioritizing pharmacological characterization of this target for anthelmintic drug...

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Detalles Bibliográficos
Autores principales: Chan, John D., Acharya, Sreemoyee, Day, Timothy A., Marchant, Jonathan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Invited Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196489/
https://www.ncbi.nlm.nih.gov/pubmed/27397763
http://dx.doi.org/10.1016/j.ijpddr.2016.06.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196489/
https://www.ncbi.nlm.nih.gov/pubmed/27397763
http://dx.doi.org/10.1016/j.ijpddr.2016.06.001

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