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Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist

5-hydroxytryptamine (5-HT) is a key regulator of muscle contraction in parasitic flatworms. In Schistosoma mansoni, the myoexcitatory action of 5-HT is effected through activation of a serotonergic GPCR (Sm.5HTR(L)), prioritizing pharmacological characterization of this target for anthelmintic drug...

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Detalles Bibliográficos
Autores principales:	Chan, John D., Acharya, Sreemoyee, Day, Timothy A., Marchant, Jonathan S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Invited Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196489/ https://www.ncbi.nlm.nih.gov/pubmed/27397763 http://dx.doi.org/10.1016/j.ijpddr.2016.06.001

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