Systemic siRNA Delivery with a Dual pH-Responsive and Tumor-targeted Nanovector for Inhibiting Tumor Growth and Spontaneous Metastasis in Orthotopic Murine Model of Breast Carcinoma

Phenylboronic acid (PBA)-mediated tumor targeting nanovector is an attractive strategy for enhancing siRNA delivery and treatment of metastatic cancers. However, its nonspecific binding with various biological membranes containing cis-diol moieties restricts its potential application by systematic a...

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Detalles Bibliográficos
Autores principales: Fan, Bo, Kang, Lin, Chen, Liqing, Sun, Ping, Jin, Mingji, Wang, Qiming, Bae, You Han, Huang, Wei, Gao, Zhonggao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197070/
https://www.ncbi.nlm.nih.gov/pubmed/28042340
http://dx.doi.org/10.7150/thno.16855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197070/
https://www.ncbi.nlm.nih.gov/pubmed/28042340
http://dx.doi.org/10.7150/thno.16855

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