Limited Tumor Tissue Drug Penetration Contributes to Primary Resistance against Angiogenesis Inhibitors

Resistance mechanisms against antiangiogenic drugs are unclear. Here, we correlated the antitumor and antivascular properties of five different antiangiogenic receptor tyrosine kinase inhibitors (RTKIs) (motesanib, pazopanib, sorafenib, sunitinib, vatalanib) with their intratumoral distribution data...

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Detalles Bibliográficos
Autores principales: Torok, Szilvia, Rezeli, Melinda, Kelemen, Olga, Vegvari, Akos, Watanabe, Kenichi, Sugihara, Yutaka, Tisza, Anna, Marton, Timea, Kovacs, Ildiko, Tovari, Jozsef, Laszlo, Viktoria, Helbich, Thomas H., Hegedus, Balazs, Klikovits, Thomas, Hoda, Mir Alireza, Klepetko, Walter, Paku, Sandor, Marko-Varga, Gyorgy, Dome, Balazs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197073/
https://www.ncbi.nlm.nih.gov/pubmed/28042343
http://dx.doi.org/10.7150/thno.16767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197073/
https://www.ncbi.nlm.nih.gov/pubmed/28042343
http://dx.doi.org/10.7150/thno.16767

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