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Applications of High-Throughput Sequencing for In Vitro Selection and Characterization of Aptamers
Aptamers are identified through an iterative process of evolutionary selection starting from a random pool containing billions of sequences. Simultaneously to the amplification of high-affinity candidates, the diversity in the pool is exponentially reduced after several rounds of in vitro selection....
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198051/ https://www.ncbi.nlm.nih.gov/pubmed/27973417 http://dx.doi.org/10.3390/ph9040076 |