Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy

Myeloperoxidase is expressed exclusively in granulocytes and immature myeloid cells and transforms the topoisomerase II (TOP2) poisons etoposide and mitoxantrone to chemical forms that have altered DNA damaging properties. TOP2 poisons are valuable and widely used anticancer drugs, but they are asso...

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Detalles Bibliográficos
Autores principales: Atwal, Mandeep, Lishman, Emma L., Austin, Caroline A., Cowell, Ian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198516/
https://www.ncbi.nlm.nih.gov/pubmed/27974636
http://dx.doi.org/10.1124/mol.116.106054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198516/
https://www.ncbi.nlm.nih.gov/pubmed/27974636
http://dx.doi.org/10.1124/mol.116.106054

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