Cargando…

Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy

Myeloperoxidase is expressed exclusively in granulocytes and immature myeloid cells and transforms the topoisomerase II (TOP2) poisons etoposide and mitoxantrone to chemical forms that have altered DNA damaging properties. TOP2 poisons are valuable and widely used anticancer drugs, but they are asso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Atwal, Mandeep, Lishman, Emma L., Austin, Caroline A., Cowell, Ian G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198516/ https://www.ncbi.nlm.nih.gov/pubmed/27974636 http://dx.doi.org/10.1124/mol.116.106054

Ejemplares similares

Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide
por: Sunter, Nicola J., et al.
Publicado: (2010)

Double-blind randomized study on the myeloprotective effect of melatonin in combination with carboplatin and etoposide in advanced lung cancer
por: Ghielmini, M, et al.
Publicado: (1999)

Improving Outcomes of Chemotherapy: Established and Novel Options for Myeloprotection in the COVID-19 Era
por: Lyman, Gary H., et al.
Publicado: (2021)

Mitoxantrone and Etoposide for the Treatment of Acute Myeloid Leukemia Patients in First Relapse
por: Im, Annie, et al.
Publicado: (2016)

Myeloprotection with activated carbon in doxorubicin-treated rats
por: Gerashchenko, Bogdan I., et al.
Publicado: (2023)

Distinct signaling events promote resistance to mitoxantrone and etoposide in pediatric AML: a Children’s Oncology Group report
por: Long, Xin, et al.
Publicado: (2017)

Antiemetic and Myeloprotective Effects of Rhus verniciflua Stoke in a Cisplatin-Induced Rat Model
por: Kim, Hyo-Seon, et al.
Publicado: (2017)

DNA Damage Inducer Mitoxantrone Amplifies Synergistic Mild‐Photothermal Chemotherapy for TNBC via Decreasing Heat Shock Protein 70 Expression
por: Chen, Zuqin, et al.
Publicado: (2023)

Biodistribution of etoposide via intratumoral chemotherapy with etoposide-loaded implants
por: Wu, Chunsheng, et al.
Publicado: (2020)

Etoposide-induced DNA damage affects multiple cellular pathways in addition to DNA damage response
por: Wei, Fengxiang, et al.
Publicado: (2018)

Salvage therapy with mitoxantrone, etoposide, bleomycin and dexamethasone for refractory or relapsed aggressive non-Hodgkin’s lymphoma patients with a poor performance status or comorbidity
por: LIN, XUEDE, et al.
Publicado: (2014)

Myeloprotective Activity of Deoxyspergualin: Influence on Splenic Colony‐forming Cell Injury and Antitumor Activity of Mitomycin C in Mice
por: Nemoto, Kyuichi, et al.
Publicado: (1992)

Design and synthesis of coumarin-based organoselenium as a new hit for myeloprotection and synergistic therapeutic efficacy in adjuvant therapy
por: Patra, Arup Ranjan, et al.
Publicado: (2018)

Etoposide damages female germ cells in the developing ovary
por: Stefansdottir, Agnes, et al.
Publicado: (2016)

Myeloprotective activity of crude methanolic leaf extract of Cassia occidentalis in cyclophosphamide-induced bone marrow suppression in Wistar rats
por: Neboh, Emeka E, et al.
Publicado: (2015)

Enhancing the Therapeutic Efficacy of Daunorubicin and Mitoxantrone with Bavachinin, Candidone, and Tephrosin
por: Darzi, Sina, et al.
Publicado: (2019)

BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response
por: Li, Zhenhai, et al.
Publicado: (2022)

Myeloperoxidase Modulates Hydrogen Peroxide Mediated Cellular Damage in Murine Macrophages
por: Guo, Chaorui, et al.
Publicado: (2020)

Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells
por: Skladanowski, A, et al.
Publicado: (2000)

Mitoxantrone and Analogues Bind and Stabilize i-Motif Forming DNA Sequences
por: Wright, Elisé P., et al.
Publicado: (2016)

Low-dosage metronomic chemotherapy and angiogenesis: topoisomerase inhibitors irinotecan and mitoxantrone stimulate VEGF-A-mediated angiogenesis
por: ALBERTSSON, PER, et al.
Publicado: (2012)

Neutrophil-derived microparticles induce myeloperoxidase-mediated damage of vascular endothelial cells
por: Pitanga, Thassila Nogueira, et al.
Publicado: (2014)

Studies on the binding affinity of anticancer drug mitoxantrone to chromatin, DNA and histone proteins
por: Hajihassan, Zahra, et al.
Publicado: (2009)

Exploratory composite endpoint demonstrates benefit of trilaciclib across multiple clinically meaningful components of myeloprotection in patients with small cell lung cancer
por: Dómine Gómez, Manuel, et al.
Publicado: (2021)

Phase I/II study of gemcitabine plus mitoxantrone as salvage chemotherapy in metastatic breast cancer
por: Lorusso, V, et al.
Publicado: (2003)

Pharmacokinetics of mitoxantrone in cancer patients treated by high-dose chemotherapy and autologous bone marrow transplantation.
por: Richard, B., et al.
Publicado: (1992)

The effect of food and concurrent chemotherapy on the bioavailability of oral etoposide.
por: Harvey, V. J., et al.
Publicado: (1985)

Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention
por: Davies, Michael J.
Publicado: (2011)

Effect of ATM and HDAC Inhibition on Etoposide-Induced DNA Damage in Porcine Early Preimplantation Embryos
por: Wang, HaiYang, et al.
Publicado: (2015)

A phase I study of OSI-461 in combination with mitoxantrone in patients with advanced solid tumors potentially responsive to mitoxantrone
por: Resta, Lee P., et al.
Publicado: (2010)

Mitoxantrone and Mitoxantrone-Loaded Iron Oxide Nanoparticles Induce Cell Death in Human Pancreatic Ductal Adenocarcinoma Cell Spheroids
por: Dinter, Jonas, et al.
Publicado: (2023)

DNA fragility at the KMT2A/MLL locus: insights from old and new technologies
por: Cowell, Ian G., et al.
Publicado: (2023)

Nanodiamond–Mitoxantrone Complexes Enhance Drug Retention in Chemoresistant Breast Cancer Cells
por: Toh, Tan-Boon, et al.
Publicado: (2014)

Randomized comparison of etoposide pharmacokinetics after oral etoposide phosphate and oral etoposide.
por: de Jong, R. S., et al.
Publicado: (1997)

Mitoxantrone-Surfactant Interactions: A Physicochemical Overview
por: Enache, Mirela, et al.
Publicado: (2016)

Late Cardiotoxicity in MS Patients Treated with Mitoxantrone
por: Najafian, Jamshid, et al.
Publicado: (2019)

In Vitro Expansion of Bone Marrow Derived Mesenchymal Stem Cells Alters DNA Double Strand Break Repair of Etoposide Induced DNA Damage
por: Hare, Ian, et al.
Publicado: (2016)

Biomarkers of Response to Etoposide-Platinum Chemotherapy in Patients with Grade 3 Neuroendocrine Neoplasms
por: Lacombe, Caroline, et al.
Publicado: (2021)

Binding mechanism of anti-cancer chemotherapeutic drug mitoxantrone to DNA characterized by magnetic tweezers
por: Kreft, Dennis, et al.
Publicado: (2018)

A Precise Nanostructure of Folate-Overhung Mitoxantrone DNA Tetrahedron for Targeted Capture Leukemia
por: Bu, Ying-Zi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_a5qq7pu2hol3fvipo8qkoqte7b