Transglutaminase 2 Inhibitor KCC009 Induces p53-Independent Radiosensitization in Lung Adenocarcinoma Cells

BACKGROUND: The expression of transglutaminase 2 (TG2) is correlated to DNA damage repair and apoptosis through the p53 pathway. The present study aimed to investigate the potential radiosensitization effect and possible mechanisms of the TG2 inhibitor KCC009 in lung cancer in vitro. MATERIAL/METHOD...

Descripción completa

Detalles Bibliográficos
Autores principales: Huayin, Sheng, Dong, Yao, Chihong, Zhu, Xiaoqian, Qian, Danying, Wan, Jianguo, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2016
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198751/
https://www.ncbi.nlm.nih.gov/pubmed/28002389
http://dx.doi.org/10.12659/MSM.901605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198751/
https://www.ncbi.nlm.nih.gov/pubmed/28002389
http://dx.doi.org/10.12659/MSM.901605

Ejemplares similares