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EWSR1/ELF5 induces acute myeloid leukemia by inhibiting p53/p21 pathway

The Ewing sarcoma breakpoint region 1 (EWSR1) gene is known to fuse with various partner genes to promote the development of the Ewing sarcoma family of tumors and other sarcomas. In contrast, the association of EWSR1 chimeric fusion genes with leukemia has rarely been reported. We identified a nove...

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Detalles Bibliográficos
Autores principales: Endo, Akifumi, Tomizawa, Daisuke, Aoki, Yuki, Morio, Tomohiro, Mizutani, Shuki, Takagi, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198945/
https://www.ncbi.nlm.nih.gov/pubmed/27627705
http://dx.doi.org/10.1111/cas.13080