2-Deoxyglucose Suppresses ERK Phosphorylation in LKB1 and Ras Wild-Type Non-Small Cell Lung Cancer Cells

Tumor cells rely on aerobic glycolysis to generate ATP, namely the "Warburg" effect. 2-deoxyglucose (2-DG) is well characterized as a glycolytic inhibitor, but its effect on cellular signaling pathways has not been fully elucidated. Herein, we sought to investigate the effect of 2-DG on ER...

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Detalles Bibliográficos
Autores principales: Sun, Linlin, Liu, Xiuju, Fu, Haian, Zhou, Wei, Zhong, Diansheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198974/
https://www.ncbi.nlm.nih.gov/pubmed/28033353
http://dx.doi.org/10.1371/journal.pone.0168793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198974/
https://www.ncbi.nlm.nih.gov/pubmed/28033353
http://dx.doi.org/10.1371/journal.pone.0168793

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