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2-Deoxyglucose Suppresses ERK Phosphorylation in LKB1 and Ras Wild-Type Non-Small Cell Lung Cancer Cells

Tumor cells rely on aerobic glycolysis to generate ATP, namely the "Warburg" effect. 2-deoxyglucose (2-DG) is well characterized as a glycolytic inhibitor, but its effect on cellular signaling pathways has not been fully elucidated. Herein, we sought to investigate the effect of 2-DG on ER...

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Detalles Bibliográficos
Autores principales:	Sun, Linlin, Liu, Xiuju, Fu, Haian, Zhou, Wei, Zhong, Diansheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198974/ https://www.ncbi.nlm.nih.gov/pubmed/28033353 http://dx.doi.org/10.1371/journal.pone.0168793

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