Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts

BACKGROUND: The BRCA2 gene product plays an important role in DNA double strand break repair. Therefore, we asked whether radiation sensitivity of pancreatic cancers developing in individuals with germline BRCA2 mutations can be enhanced by agents that inhibit poly (ADP-ribose) polymerase (PARP). ME...

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Detalles Bibliográficos
Autores principales: Lohse, Ines, Kumareswaran, Ramya, Cao, Pinjiang, Pitcher, Bethany, Gallinger, Steven, Bristow, Robert G., Hedley, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199060/
https://www.ncbi.nlm.nih.gov/pubmed/28033382
http://dx.doi.org/10.1371/journal.pone.0167272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199060/
https://www.ncbi.nlm.nih.gov/pubmed/28033382
http://dx.doi.org/10.1371/journal.pone.0167272

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