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PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS

BACKGROUND: The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are associated with breast cancer risk as high as those associated with rare BRCA2...

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Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5200636/
https://www.ncbi.nlm.nih.gov/pubmed/27595995
http://dx.doi.org/10.1136/jmedgenet-2016-103839