Polyglutamine length-dependent toxicity from α1ACT in Drosophila models of spinocerebellar ataxia type 6

Spinocerebellar ataxia type 6 (SCA6) is a neurodegenerative disease that results from abnormal expansion of a polyglutamine (polyQ) repeat. SCA6 is caused by CAG triplet repeat expansion in the gene CACNA1A, resulting in a polyQ tract of 19-33 in patients. CACNA1A, a bicistronic gene, encodes the α1...

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Detalles Bibliográficos
Autores principales: Tsou, Wei-Ling, Qiblawi, Sultan H., Hosking, Ryan R., Gomez, Christopher M., Todi, Sokol V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5200913/
https://www.ncbi.nlm.nih.gov/pubmed/27979829
http://dx.doi.org/10.1242/bio.021667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5200913/
https://www.ncbi.nlm.nih.gov/pubmed/27979829
http://dx.doi.org/10.1242/bio.021667

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